An exported kinase (FIKK4.2) that mediates virulence-associated changes in Plasmodium falciparum-infected red blood cells.
Identifieur interne : 003C10 ( Main/Exploration ); précédent : 003C09; suivant : 003C11An exported kinase (FIKK4.2) that mediates virulence-associated changes in Plasmodium falciparum-infected red blood cells.
Auteurs : Lev M. Kats [Australie] ; Kate M. Fernandez [Australie] ; Fiona K. Glenister [Australie] ; Susann Herrmann [Australie] ; Donna W. Buckingham [Australie] ; Ghizal Siddiqui [Australie] ; Laveena Sharma [Australie] ; Rebecca Bamert [Australie] ; Isabelle Lucet [Australie] ; Micheline Guillotte [France] ; Odile Mercereau-Puijalon [France] ; Brian M. Cooke [Australie]Source :
- International journal for parasitology [ 1879-0135 ] ; 2014.
Descripteurs français
- KwdFr :
- Facteurs de virulence (génétique), Facteurs de virulence (métabolisme), Humains, Phosphotransferases (génétique), Phosphotransferases (métabolisme), Plasmodium falciparum (enzymologie), Plasmodium falciparum (génétique), Techniques de knock-out de gènes, Transport de protéines, Érythrocytes (parasitologie).
- MESH :
- enzymologie : Plasmodium falciparum.
- génétique : Facteurs de virulence, Phosphotransferases, Plasmodium falciparum.
- métabolisme : Facteurs de virulence, Phosphotransferases.
- parasitologie : Érythrocytes.
- Humains, Techniques de knock-out de gènes, Transport de protéines.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Phosphotransferases, Virulence Factors.
- chemical , metabolism : Phosphotransferases, Virulence Factors.
- enzymology : Plasmodium falciparum.
- genetics : Plasmodium falciparum.
- parasitology : Erythrocytes.
- Gene Knockout Techniques, Humans, Protein Transport.
Abstract
Alteration of the adhesive and mechanical properties of red blood cells caused by infection with the malaria parasite Plasmodium falciparum underpin both its survival and extreme pathogenicity. A unique family of parasite putative exported kinases, collectively called FIKK (Phenylalanine (F) - Isoleucine (I) - Lysine (K) - Lysine (K)), has recently been implicated in these pathophysiological processes, however, their precise function in P. falciparum-infected red blood cells or their likely role in malaria pathogenesis remain unknown. Here, for the first time, we demonstrate that one member of the FIKK family, FIKK4.2, can function as an active kinase and is localised in a novel and distinct compartment of the parasite-infected red blood cell which we have called K-dots. Notably, targeted disruption of the gene encoding FIKK4.2 (fikk4.2) dramatically alters the parasite's ability to modify and remodel the red blood cells in which it multiplies. Specifically, red blood cells infected with fikk4.2 knockout parasites were significantly less rigid and less adhesive when compared with red blood cells infected with normal parasites from which the transgenic clones had been derived, despite expressing similar levels of the major cytoadhesion ligand, PfEMP1, on the red blood cell surface. Notably, these changes were accompanied by dramatically altered knob-structures on infected red blood cells that play a key role in cytoadhesion which is responsible for much of the pathogenesis associated with falciparum malaria. Taken together, our data identifies FIKK4.2 as an important kinase in the pathogenesis of P. falciparum malaria and strengthens the attractiveness of FIKK kinases as targets for the development of novel next-generation anti-malaria drugs.
DOI: 10.1016/j.ijpara.2014.01.003
PubMed: 24530877
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003854
- to stream PubMed, to step Curation: 003740
- to stream PubMed, to step Checkpoint: 003740
- to stream Ncbi, to step Merge: 001789
- to stream Ncbi, to step Curation: 001789
- to stream Ncbi, to step Checkpoint: 001789
- to stream Main, to step Merge: 003C60
- to stream Main, to step Curation: 003C10
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An exported kinase (FIKK4.2) that mediates virulence-associated changes in Plasmodium falciparum-infected red blood cells.</title><author><name sortKey="Kats, Lev M" sort="Kats, Lev M" uniqKey="Kats L" first="Lev M" last="Kats">Lev M. Kats</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez, Kate M" sort="Fernandez, Kate M" uniqKey="Fernandez K" first="Kate M" last="Fernandez">Kate M. Fernandez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Glenister, Fiona K" sort="Glenister, Fiona K" uniqKey="Glenister F" first="Fiona K" last="Glenister">Fiona K. Glenister</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Herrmann, Susann" sort="Herrmann, Susann" uniqKey="Herrmann S" first="Susann" last="Herrmann">Susann Herrmann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Buckingham, Donna W" sort="Buckingham, Donna W" uniqKey="Buckingham D" first="Donna W" last="Buckingham">Donna W. Buckingham</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Siddiqui, Ghizal" sort="Siddiqui, Ghizal" uniqKey="Siddiqui G" first="Ghizal" last="Siddiqui">Ghizal Siddiqui</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Laveena" sort="Sharma, Laveena" uniqKey="Sharma L" first="Laveena" last="Sharma">Laveena Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Bamert, Rebecca" sort="Bamert, Rebecca" uniqKey="Bamert R" first="Rebecca" last="Bamert">Rebecca Bamert</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Lucet, Isabelle" sort="Lucet, Isabelle" uniqKey="Lucet I" first="Isabelle" last="Lucet">Isabelle Lucet</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Guillotte, Micheline" sort="Guillotte, Micheline" uniqKey="Guillotte M" first="Micheline" last="Guillotte">Micheline Guillotte</name><affiliation wicri:level="3"><nlm:affiliation>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Paris, France; Centre National de la Recherche Scientifique, URA 2581, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Paris, France; Centre National de la Recherche Scientifique, URA 2581, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mercereau Puijalon, Odile" sort="Mercereau Puijalon, Odile" uniqKey="Mercereau Puijalon O" first="Odile" last="Mercereau-Puijalon">Odile Mercereau-Puijalon</name><affiliation wicri:level="3"><nlm:affiliation>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Paris, France; Centre National de la Recherche Scientifique, URA 2581, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Paris, France; Centre National de la Recherche Scientifique, URA 2581, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cooke, Brian M" sort="Cooke, Brian M" uniqKey="Cooke B" first="Brian M" last="Cooke">Brian M. Cooke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia. Electronic address: brian.cooke@monash.edu.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24530877</idno><idno type="pmid">24530877</idno><idno type="doi">10.1016/j.ijpara.2014.01.003</idno><idno type="wicri:Area/PubMed/Corpus">003854</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003854</idno><idno type="wicri:Area/PubMed/Curation">003740</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003740</idno><idno type="wicri:Area/PubMed/Checkpoint">003740</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003740</idno><idno type="wicri:Area/Ncbi/Merge">001789</idno><idno type="wicri:Area/Ncbi/Curation">001789</idno><idno type="wicri:Area/Ncbi/Checkpoint">001789</idno><idno type="wicri:Area/Main/Merge">003C60</idno><idno type="wicri:Area/Main/Curation">003C10</idno><idno type="wicri:Area/Main/Exploration">003C10</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">An exported kinase (FIKK4.2) that mediates virulence-associated changes in Plasmodium falciparum-infected red blood cells.</title><author><name sortKey="Kats, Lev M" sort="Kats, Lev M" uniqKey="Kats L" first="Lev M" last="Kats">Lev M. Kats</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez, Kate M" sort="Fernandez, Kate M" uniqKey="Fernandez K" first="Kate M" last="Fernandez">Kate M. Fernandez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Glenister, Fiona K" sort="Glenister, Fiona K" uniqKey="Glenister F" first="Fiona K" last="Glenister">Fiona K. Glenister</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Herrmann, Susann" sort="Herrmann, Susann" uniqKey="Herrmann S" first="Susann" last="Herrmann">Susann Herrmann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Buckingham, Donna W" sort="Buckingham, Donna W" uniqKey="Buckingham D" first="Donna W" last="Buckingham">Donna W. Buckingham</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Siddiqui, Ghizal" sort="Siddiqui, Ghizal" uniqKey="Siddiqui G" first="Ghizal" last="Siddiqui">Ghizal Siddiqui</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Laveena" sort="Sharma, Laveena" uniqKey="Sharma L" first="Laveena" last="Sharma">Laveena Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Bamert, Rebecca" sort="Bamert, Rebecca" uniqKey="Bamert R" first="Rebecca" last="Bamert">Rebecca Bamert</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Lucet, Isabelle" sort="Lucet, Isabelle" uniqKey="Lucet I" first="Isabelle" last="Lucet">Isabelle Lucet</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Guillotte, Micheline" sort="Guillotte, Micheline" uniqKey="Guillotte M" first="Micheline" last="Guillotte">Micheline Guillotte</name><affiliation wicri:level="3"><nlm:affiliation>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Paris, France; Centre National de la Recherche Scientifique, URA 2581, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Paris, France; Centre National de la Recherche Scientifique, URA 2581, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mercereau Puijalon, Odile" sort="Mercereau Puijalon, Odile" uniqKey="Mercereau Puijalon O" first="Odile" last="Mercereau-Puijalon">Odile Mercereau-Puijalon</name><affiliation wicri:level="3"><nlm:affiliation>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Paris, France; Centre National de la Recherche Scientifique, URA 2581, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Paris, France; Centre National de la Recherche Scientifique, URA 2581, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cooke, Brian M" sort="Cooke, Brian M" uniqKey="Cooke B" first="Brian M" last="Cooke">Brian M. Cooke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia. Electronic address: brian.cooke@monash.edu.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author></analytic><series><title level="j">International journal for parasitology</title><idno type="eISSN">1879-0135</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Erythrocytes (parasitology)</term><term>Gene Knockout Techniques</term><term>Humans</term><term>Phosphotransferases (genetics)</term><term>Phosphotransferases (metabolism)</term><term>Plasmodium falciparum (enzymology)</term><term>Plasmodium falciparum (genetics)</term><term>Protein Transport</term><term>Virulence Factors (genetics)</term><term>Virulence Factors (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Facteurs de virulence (génétique)</term><term>Facteurs de virulence (métabolisme)</term><term>Humains</term><term>Phosphotransferases (génétique)</term><term>Phosphotransferases (métabolisme)</term><term>Plasmodium falciparum (enzymologie)</term><term>Plasmodium falciparum (génétique)</term><term>Techniques de knock-out de gènes</term><term>Transport de protéines</term><term>Érythrocytes (parasitologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Phosphotransferases</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Phosphotransferases</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de virulence</term><term>Phosphotransferases</term><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de virulence</term><term>Phosphotransferases</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Érythrocytes</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Erythrocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Knockout Techniques</term><term>Humans</term><term>Protein Transport</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Techniques de knock-out de gènes</term><term>Transport de protéines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alteration of the adhesive and mechanical properties of red blood cells caused by infection with the malaria parasite Plasmodium falciparum underpin both its survival and extreme pathogenicity. A unique family of parasite putative exported kinases, collectively called FIKK (Phenylalanine (F) - Isoleucine (I) - Lysine (K) - Lysine (K)), has recently been implicated in these pathophysiological processes, however, their precise function in P. falciparum-infected red blood cells or their likely role in malaria pathogenesis remain unknown. Here, for the first time, we demonstrate that one member of the FIKK family, FIKK4.2, can function as an active kinase and is localised in a novel and distinct compartment of the parasite-infected red blood cell which we have called K-dots. Notably, targeted disruption of the gene encoding FIKK4.2 (fikk4.2) dramatically alters the parasite's ability to modify and remodel the red blood cells in which it multiplies. Specifically, red blood cells infected with fikk4.2 knockout parasites were significantly less rigid and less adhesive when compared with red blood cells infected with normal parasites from which the transgenic clones had been derived, despite expressing similar levels of the major cytoadhesion ligand, PfEMP1, on the red blood cell surface. Notably, these changes were accompanied by dramatically altered knob-structures on infected red blood cells that play a key role in cytoadhesion which is responsible for much of the pathogenesis associated with falciparum malaria. Taken together, our data identifies FIKK4.2 as an important kinase in the pathogenesis of P. falciparum malaria and strengthens the attractiveness of FIKK kinases as targets for the development of novel next-generation anti-malaria drugs.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Kats, Lev M" sort="Kats, Lev M" uniqKey="Kats L" first="Lev M" last="Kats">Lev M. Kats</name></noRegion><name sortKey="Bamert, Rebecca" sort="Bamert, Rebecca" uniqKey="Bamert R" first="Rebecca" last="Bamert">Rebecca Bamert</name><name sortKey="Buckingham, Donna W" sort="Buckingham, Donna W" uniqKey="Buckingham D" first="Donna W" last="Buckingham">Donna W. Buckingham</name><name sortKey="Cooke, Brian M" sort="Cooke, Brian M" uniqKey="Cooke B" first="Brian M" last="Cooke">Brian M. Cooke</name><name sortKey="Fernandez, Kate M" sort="Fernandez, Kate M" uniqKey="Fernandez K" first="Kate M" last="Fernandez">Kate M. Fernandez</name><name sortKey="Glenister, Fiona K" sort="Glenister, Fiona K" uniqKey="Glenister F" first="Fiona K" last="Glenister">Fiona K. Glenister</name><name sortKey="Herrmann, Susann" sort="Herrmann, Susann" uniqKey="Herrmann S" first="Susann" last="Herrmann">Susann Herrmann</name><name sortKey="Lucet, Isabelle" sort="Lucet, Isabelle" uniqKey="Lucet I" first="Isabelle" last="Lucet">Isabelle Lucet</name><name sortKey="Sharma, Laveena" sort="Sharma, Laveena" uniqKey="Sharma L" first="Laveena" last="Sharma">Laveena Sharma</name><name sortKey="Siddiqui, Ghizal" sort="Siddiqui, Ghizal" uniqKey="Siddiqui G" first="Ghizal" last="Siddiqui">Ghizal Siddiqui</name></country><country name="France"><region name="Île-de-France"><name sortKey="Guillotte, Micheline" sort="Guillotte, Micheline" uniqKey="Guillotte M" first="Micheline" last="Guillotte">Micheline Guillotte</name></region><name sortKey="Mercereau Puijalon, Odile" sort="Mercereau Puijalon, Odile" uniqKey="Mercereau Puijalon O" first="Odile" last="Mercereau-Puijalon">Odile Mercereau-Puijalon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003C10 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003C10 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24530877
|texte= An exported kinase (FIKK4.2) that mediates virulence-associated changes in Plasmodium falciparum-infected red blood cells.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24530877" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |